General Information

  • ID:  hor003206
  • Uniprot ID:  NA
  • Protein name:  Nociceptin
  • Gene name:  NA
  • Organism:  Cepaea nemoralis
  • Family:  Opioid neuropeptide precursor family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  FGFTGARKSARKLANQ
  • Length:  16
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor003206_AF2.pdbhor003206_ESM.pdb

Physical Information

Mass: 201974 Formula: C77H126N26O21
Absent amino acids: CDEHIMPVWY Common amino acids: A
pI: 12.53 Basic residues: 4
Polar residues: 5 Hydrophobic residues: 6
Hydrophobicity: -70.63 Boman Index: -4090
Half-Life / Aliphatic Index: 1.1 hour Aliphatic Index: 43.13
Instability Index: -1125.63 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  9357050
  • Title:  The NMDA Receptor Antagonist, NPC 12626, Reduces the Pronociceptive Effects of Orphanin FQ and Kappa Opiate Antinociception in the Land Snail, Cepaea Nemoralis